4-HO-MET Fumarate

4-HO-MET Fumarate

• IUPAC Name: 3-(2-(ethyl(methyl)amino)ethyl)-1H-indol-4-ol fumarate
• Molecular Formula: C₁₃H₁₈N₂O · C₄H₄O₄
• CAS Registry Number: 77872-41-4 (free base); salt CAS not yet assigned
• Salt Form: Fumarate (1:1) – enhances stability, shelf-life and water solubility versus free base.

• Appearance: Fluffy off-white to very pale-brown microcrystalline powder ≥ 98 % (HPLC, area %)
• Melting Point: 152 – 156 °C (dec.)
• Solubility: 18 mg mL⁻¹ in pH 4 buffer; freely soluble in DMSO, 0.1 M HCl, 10 % HP-β-CD; sparingly soluble in water; practically insoluble in non-polar solvents.
• Storage: −20 °C, desiccated, away from light and oxygen; stable ≥ 36 months when unopened. Re-test after 12 months once vial is breached.
• Shipping: Ambient temperature; non-controlled in most territories (buyer must confirm local legislation).

• Class: 4-hydroxy-N-methyl-N-ethyl-tryptamine; “metocin”; structural analogue of psilocin (4-HO-DMT).
• Receptor Signature: High-efficacy 5-HT₂A agonist (Ki = 7.3 nM, EC₅₀ = 4.2 nM); 5-HT₂C (Ki = 12 nM); negligible activity at dopaminergic, adrenergic or monoamine transporters (IC₅₀ > 10 µM).
• Predicted Behaviour: Rapid onset (10–20 min i.p. in rodents), peak 60–90 min, total duration 4–6 h; produces head-twitch response (HTR) with ED₅₀ ≈ 0.7 mg kg⁻¹, a validated proxy for psychedelic potency.
• Metabolism: O-glucuronidation and N-de-ethylation; primarily hepatic via UGT1A9 & CYP2D6; renal excretion of conjugates.

• Status: Research chemical – strictly NOT for human or veterinary use.
• PPE: Nitrile gloves, FFP-2 mask, safety glasses; weigh inside a negative-pressure glove box or fume hood.
• Legal Note: Schedule-unlisted in most jurisdictions, but may be controlled by analogue or tryptamine-catch-all provisions; customer responsible for verifying licences.
• Documentation: QR-coded COA includes ¹H-NMR, ¹³C-NMR, LC-MS, residual solvents (≤ 0.05 % MeOH, ≤ 0.02 % DMF), elemental micro-analysis, fumaric acid content (≤ 0.3 % w/w), and microbial/endotoxin screen for in-vivo lots.